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With butyl group chemically attached to the modified non-porous poly(styrene divinylbenzene) (PS/DVB) beads, Proteomix® HIC Butyl columns provide high resolution hydrophobic interaction separation for biomolecules such as mAb, ADCs and their fragments.   With proprietary surface modification that minimizes non-specific binding, MonomixTM MC SEC resins are highly stable over a broad pH tolerance range (1-14), an advantage over silica-based SEC resins, and compatible with many commonly used organic solvents and aqueous buffers. A full Antibody Drug Conjugates (ADCs) chromatographic separation solution includes Zenix®-C SEC for analysis of ADCs aggregate, monomer, fragment and free drug, Proteomix® HIC Butyl and RP-1000 for Drug to Antibody Ratio (DAR) analysis, and Proteomix® and Antibodix® IEX for ADCs charge variants studies.
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