Monomix H2P-SAX columns are designed to effectively quantify neutral amphiphilic surfactants, such as Tween 80, Tween 20, and Poloxamers,
which are commonly present in formulated biological samples, such as Monoclonal Antibodies. The rigid and spherical solid
support of the resin is composed of highly cross-linked poly(styrene/divinylbenzene/modifier) (PS/DVB/M). The average particle size is 40 µm,
with a narrow size distribution (D90/D10 < 1.3), and ideal porous structure and robust chemical/physical stability.
The polymeric porous beads are further covalently modified with mixed-mode ligands so that the beads are water wettable,
and at the same time can absorb amphiphilic surfactants.
Technical Specifications
Application
Surfactant quantification
Brand
Monomix H2P-SAX
Chemistry
Mixed-Mode
Ion exchange capacity
0.5 meq/gram
Mass spec. compatibility
Yes
Particle size
40 µm
Water wettable
Yes
pH stability
1-13
Operating temperature limit
80 ℃
Operating pressure limit
3,000 psi
Mobile phase compatibility
Aqueous solvents, organic solvents, or their mixtures
[1] Guard column [2] One-piece PEEK coupler, recommended to connect columns in series. [3] PEEK/Stainless Steel coupler, recommended to connect columns of IDs > 7.8 mm in series. [4] Column coupler with 10cm length flexible tubing,10-32 fitting with 1/16 OD PEEK tubing. Recommended to connect analytical columns in series