Monomix^TM Aminodiol

Sepax Monomix MC30-Aminodiol Affinity Resin: 30 μm narrowly dispersed polymethacrylate rigid base bead is functionalized with a polyhydroxylated surface coating layer that provides a bio-inert surface and shows low non-specific binding to biomolecules. Aminodiol group is then conjugated to bead surface through an innovative method (patent pending). The resulting affinity resin is applicable for the isolation and purification of boron-containing molecules including large biomolecules.

Monomix MC30-Aminodiol affinity resin and column fill gaps in existing purification technologies and cover both analytical market needs and industrial purification market needs. The key benefits are higher separation efficiency, higher purification throughput, and overall lower purification cost compared with conventional RP, IEX, and recrystallization purification.

Features

• Specific binding to boron-containing molecules
• Provides efficient capture and release under mild and straight forward purification conditions, simplify subsequent purification steps and maximize overall production efficiency
• Decreases process development time and enhances productivity
• No need to use a lot of organic solvents. High biocompatibility, and can better maintain the biological activity of purified molecules
• Produce less chemical wastes (liquid and solid) which are easy to be treated. Reduce risk of safety and environmental pollution
• Chromatography medium and column can be cleaned and reused many times
• Excellent scalability. Provide prepacked analytical columns, semi-prep columns, prep columns and bulk loose resin
• Resin customization: can provide polymethyl methacrylate beads with 10, 15, 30 and 60 µm bead size and other matrix beads
• Innovative chromatography medium and column, enable a platform affinity chromatography technology for boron-containing molecules purification

Technical Specifications

Bulk Resin

Pre-packed Stainless Steel Columns

• Boron-containing molecules as proteasome inhibitor, for example, Bortezomib and Ixazomib
• Boron-containing boronic acid molecules as antifungal, antibacterial, and antiviral drugs. Tavaborole, Crisaborole and Vaborbactam
• Boron compounds and boron containing biomolecules used in Boron Neutron Capture Therapy (BNCT). Borofalan (Steboronine) and boron-containing acridine derivatives and antibody boron conjugates.
• Boron-containing compounds with thrombin inhibitory activity
• Boron containing intermediates used in organic chemistry synthesis which are very useful to introduce versatile
functional groups. Boron compound used in boron selective reaction for molecular modular synthesis
• Chiral peptide separation. - C*-B-  chiral carbon is next to a boron atom
• Used to recover unreacted or excess boron-containing reagents in chemical reactions. For example for a reaction between solid surfaces or polymers with soluble boron-containing reagents

Isolation and Purification of Boron-containing Compounds with Sepax Monomix MC30-Aminodiol